abstract：BACKGROUND:Umbilical cord blood (UCB) processing with hydroxyethyl starch (HES) is the most common protocol in the cord blood banks. The quality of UCB volume reduction was guaranteed by minimum manipulation of cord blood samples in the closed system. This study aimed to analyze and compare cell recovery and viability ...

journal_title：Transfusion

authors： Souri M,Nikougoftar Zarif M,Rasouli M,Golzadeh K,Nakhlestani Hagh M,Ezzati N,Atarodi K

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. CASE REPORT:A 59-year-old male patient developed severe thromb...

journal_title：Transfusion

authors： Huang R,Cai GQ,Zhang JH,Liu FX,Ma JQ,Liu H,Nie XM,Gui R

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Development of de novo alloantibodies against recipient's red blood cell (RBC) antigens by engrafted donor's lymphocytes is a known phenomenon in the setting of allogeneic hematopoietic stem cell transplantation (HSCT). This situation is usually clinically insignificant. We report a case of early clinically ...

journal_title：Transfusion

authors： Bailén R,Kwon M,Pérez-Corral AM,Pascual C,Buño I,Balsalobre P,Serrano D,Gayoso J,Díez-Martín JL,Anguita J

更新日期：2017-10-01 00:00:00

abstract：:Transfusion medicine (TM) physicians provide medical services that benefit all patients such as providing 24-hour laboratory coverage, advising health care providers on test interpretation and selection, validating new methods, and supervising technical personnel. These services ensure delivery of accurate, reliable, ...

journal_title：Transfusion

authors： Jhang JS,Francis RO,Winkler A,Tormey C

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Transfusion-transmitted babesiosis (TTB) has been rapidly increasing in incidence since the beginning of the 21st century. Asymptomatic individuals with Babesia infection are able to donate blood in the United States because of the lack of specific blood donation testing. Blood products collected in Babesia-...

journal_title：Transfusion

authors： LeBel DP 2nd,Moritz ED,O'Brien JJ,Lazarchick J,Tormos LM,Duong A,Fontaine MJ,Squires JE,Stramer SL

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Factor (F)XIII deficiency is a rare inherited bleeding disorder, but can also be acquired due to the development of inhibitors. CASE REPORT:A 17-year-old female with systemic lupus erythematosus and end-stage kidney disease secondary to Class IV lupus nephritis developed spontaneous subcutaneous and muscula...

journal_title：Transfusion

authors： Rabik CA,Atkinson MA,Sule S,Strouse JJ

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus 1 (HIV-1) subtype B is predominant in Spain. However, the recent arrival of immigrant populations has increased the prevalence of non-B subtypes and circulating recombinant forms. The objective of this study was to determine the prevalence of HIV-1 subtypes and transmitted drug-r...

journal_title：Transfusion

authors： Bes M,Piron M,Casamitjana N,Gregori J,Esteban JI,Ribera E,Quer J,Puig L,Sauleda S

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:CD34 flow cytometry is the gold standard for stem cell enumeration in peripheral blood at the mobilization stage and in the final apheresis product. The new stem cell mode of the Sysmex XN Series analyzer enumerates an immature cell population in the white progenitor and pathological cell (WPC) channel, base...

journal_title：Transfusion

authors： Grommé M,Russcher H,Braakman E,Klinkspoor JH,Dobber JA,de Greef I,de Wit NCJ

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Iron deficiency represents a risk to donor health and the blood supply. Efficacy trials indicate that postdonation iron replacement improves iron stores but they do not account for complexities of implementation in the routine collection context. We therefore conducted two prospective feasibility studies in ...

journal_title：Transfusion

authors： Pasricha SR,Marks DC,Salvin H,Brama T,Keller AJ,Pink J,Speedy J

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Acoustic cell separation uses ultrasound waves to separate cells from plasma to perform plasmapheresis. Although the fundamental process has been studied for decades, no acoustic cell separation has been studied in a disposable plastic format suitable for clinical applications. STUDY DESIGN AND METHODS:We d...

journal_title：Transfusion

authors： Savage WJ,Burns JR,Fiering J

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Tests for platelet-specific antibodies are important in the diagnosis of immune platelet disorders. Monoclonal antibody glycoprotein capture assays have been the gold standards in platelet antibody detection for almost 30 years. However, such assays are complex and cumbersome to perform, which limits their r...

journal_title：Transfusion

authors： Metzner K,Bauer J,Ponzi H,Ujcich A,Curtis BR

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Direct oral anticoagulants (DOACs) are effective and safe for prophylaxis and treatment of thromboembolic phenomena. However, managing DOACs during bleeding emergencies is challenging. A systematic review and meta-analysis was conducted on studies addressing efficacy and safety of the drugs used for reversal...

journal_title：Transfusion

authors： da Luz LT,Marchand M,Nascimento B,Tien H,Nathens A,Shah P

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Although the risk of transmitting infectious agents by blood transfusion is dramatically reduced after donor selection, leukoreduction, and laboratory testing, some could still be present in donor's blood. A description of metagenomes in blood products eligible for transfusion represents relevant information...

journal_title：Transfusion

authors： Lau P,Cordey S,Brito F,Tirefort D,Petty TJ,Turin L,Guichebaron A,Docquier M,Zdobnov EM,Waldvogel-Abramowski S,Lecompte T,Kaiser L,Preynat-Seauve O

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Routine quantification of platelet-derived extracellular vesicles (PL-EVs) may be useful in the quality control (QC) of platelet concentrates (PCs). The aim of this multicenter study was to establish and validate a consensus protocol for the standardized PL-EV quantification using conventional flow cytometer...

journal_title：Transfusion

authors： Black A,Orsó E,Kelsch R,Pereira M,Kamhieh-Milz J,Salama A,Fischer MB,Meyer E,Frey BM,Schmitz G

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Recently, a quasi-lipid-enveloped (LE) form of the traditionally nonlipid-enveloped (NLE) hepatitis A virus (HAV) was described in human serum and cell culture-derived HAV stocks. This discovery challenges the understanding of HAV reduction in virus clearance studies of plasma products, which were performed ...

journal_title：Transfusion

authors： Kapsch AM,Farcet MR,Antoine G,Kreil TR

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:In August 2016, the Food and Drug Administration advised US blood centers to screen all whole blood and apheresis donations for Zika virus (ZIKV) with an individual-donor nucleic acid test (ID-NAT) or to use approved pathogen reduction technology (PRT). The cost of implementing this guidance nationally has n...

journal_title：Transfusion

authors： Ellingson KD,Sapiano MRP,Haass KA,Savinkina AA,Baker ML,Henry RA,Berger JJ,Kuehnert MJ,Basavaraju SV

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Bacterial contamination of blood components remains a major cause of sepsis in transfusion medicine. Between 2006 and 2010 in the 5 years before the introduction of bacterial screening of platelet (PLT) components by National Health Service Blood and Transplant (NHSBT), seven cases of PLT component-associate...

journal_title：Transfusion

authors： McDonald C,Allen J,Brailsford S,Roy A,Ball J,Moule R,Vasconcelos M,Morrison R,Pitt T

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Beriplex P/N/Kcentra/Coaplex/Confidex is a four-factor human prothrombin complex concentrate (PCC). Here, we describe the pathogen safety profile and biochemical characteristics of an improved manufacturing process that further enhances the virus safety of Beriplex P/N. STUDY DESIGN AND METHODS:Samples of p...

journal_title：Transfusion

authors： Nowak T,Popp B,Gröner A,Schäfer W,Kalina U,Enssle K,Roth NJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Alloimmunization against human platelet antigens (HPAs) during pregnancy is rare but can lead to severe bleeding disorders, such as fetal and neonatal alloimmune thrombocytopenia. STUDY DESIGN AND METHODS:In a cohort of 241 uncomplicated pregnancies, we investigated the immunogenicity of HPA mismatches and ...

journal_title：Transfusion

authors： Reiher VSA,Hönger G,Infanti L,Passweg JR,Hösli I,Frey BM,Gassner C,Meyer S,Buser AS,Holbro A,Schaub S

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Plasma thawed and stored at 1 to 6° C for up to 5 days (thawed plasma [TP]) provides rapid availability in emergencies and reduces plasma waste, but it carries risks of coagulation factor loss or activation, bacterial outgrowth, and viral contamination. We characterized changes in amotosalen/ultraviolet A (U...

journal_title：Transfusion

authors： Erickson A,Waldhaus K,David T,Huang N,Rico S,Corash L,Mufti N,Benjamin RJ

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Variant Creutzfeldt-Jakob disease (vCJD) has been transmitted by blood transfusion (TTvCJD). The US Food and Drug Administration (FDA) recommends deferring blood donors who resided in or traveled to 30 European countries where they may have been exposed to bovine spongiform encephalopathy (BSE) through beef ...

journal_title：Transfusion

authors： Yang H,Huang Y,Gregori L,Asher DM,Bui T,Forshee RA,Anderson SA

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The ABO system is of fundamental importance in the fields of transfusion and transplantation and has apparent associations with certain diseases, including cardiovascular disorders. ABO expression is reduced in the late phase of erythroid differentiation in vitro, whereas histone deacetylase inhibitors (HDAC...

journal_title：Transfusion

authors： Takahashi Y,Kubo R,Sano R,Nakajima T,Takahashi K,Kobayashi M,Handa H,Tsukada J,Kominato Y

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) has spread in the Americas, including parts of the southern United States, and infection can be associated with serious complications, including congenital brain abnormalities. Probable transfusion transmission of ZIKV has been documented in Brazil. STUDY DESIGN AND METHODS:Preemptive test...

journal_title：Transfusion

authors： Galel SA,Williamson PC,Busch MP,Stanek D,Bakkour S,Stone M,Lu K,Jones S,Rossmann SN,Pate LL,cobas Zika IND Study Group.

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Exposure to blood products during pregnancy carries a potential risk of transfusion transmission of infectious agents. Blood agencies have historically sought optimal deferral and testing strategies to protect blood supplies in part to ensure the protection of pregnant women and their unborn infants. The Zik...

journal_title：Transfusion

authors： Murphy MS,Shehata N,Colas JA,Chassé M,Fergusson DA,O'Brien SF,Goldman M,Tinmouth A,Forster AJ,Wilson K

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:If anti-hepatitis B core antibody testing is not mandated blood donors with occult hepatitis B infection (OBI) may transmit hepatitis B virus (HBV) to a recipient in spite of the use of nucleic acid amplification technology (NAT) or pathogen inactivation (PI). STUDY DESIGN AND METHODS:We developed a model t...

journal_title：Transfusion

authors： Weusten J,van Drimmelen H,Vermeulen M,Lelie N

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The storage duration of platelet (PLT) units is limited to 5 to 7 days. This study investigates whether PLT storage duration is associated with patient outcomes in critically ill patients. STUDY DESIGN AND METHODS:This study was a retrospective analysis of critically ill patients admitted to the intensive c...

journal_title：Transfusion

authors： Flint A,Aubron C,Bailey M,Bellomo R,Pilcher D,Cheng AC,Hegarty C,Reade MC,McQuilten Z

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:A previous study in our hospitals correlated suboptimal documentation and failure to justify transfusions. In light of implemented blood-conservation strategies, including patient blood management (PBM) and prospective audits (PAs), we performed a follow-up study. STUDY DESIGN AND METHODS:We reviewed prospe...

journal_title：Transfusion

authors： Madrigal E,Prajapati S,Avadhani V,Annen K,Friedman MT

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Patients presenting with acute episodes of thrombotic microangiopathies (TMAs) require urgent access to plasma exchange (PEX). OctaplasLG, a solvent/detergent fresh-frozen plasma product that has undergone viral inactivation and prion reduction step, has been used in our institution since 2013, replacing Oct...

journal_title：Transfusion

authors： Vendramin C,McGuckin S,Alwan F,Westwood JP,Thomas M,Scully M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Intravenous immunoglobulin G (IVIG) replacement therapy is used to prevent invasive infections in patients with primary antibody deficiency (PAD). However, few studies have functionally evaluated specific antibodies against encapsulated bacteria that cause invasive infection in patients with PAD. In this stu...

journal_title：Transfusion

authors： Lee S,Kim HW,Kim KH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Improving apheresis technology may lead to an efficient and safe peripheral blood stem cell (PBSC) collection. Recently, the Spectra Optia (Optia, Terumo BCT) was introduced as an automated apheresis instrument, but comparisons with other instruments have been few. This is the first randomized multicenter an...

journal_title：Transfusion

authors： Ikeda K,Minakawa K,Muroi K,Fujiwara SI,Yamada-Fujiwara M,Fujimori Y,Tanosaki R,Ohto H,Study Group for Peripheral Blood Stem Cell Collection, Cell Therapy Committee, The Japan Society of Transfusion Medicine and Cell Therapy.

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Chronic red blood cell (RBC) transfusion therapy (CTT) is an integral component of the management of severe sickle cell disease (SCD) and can prevent complications, such as stroke. RBC units can be administered via simple transfusion or exchange transfusion, and erythrocytapheresis (automated RBC exchange tr...

journal_title：Transfusion

authors： Kelly S,Quirolo K,Marsh A,Neumayr L,Garcia A,Custer B

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:There has been increased worldwide emphasis on the many benefits of human immunodeficiency virus (HIV) serostatus awareness for both infection prevention and improved treatment outcomes. Previous studies indicate that donors may use blood donation to be tested; the objectives of this analysis were to assess,...

journal_title：Transfusion

authors： Bruhn R,Moreno E,Sabino EC,Ferreira NA,Carneiro-Proietti AB,Lopes ME,Sampaio D,Loureiro P,Custer B,Goncalez TT,National Heart, Lung and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II) International Component.

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:ABO is a blood group system of high clinical significance due to the prevalence of ABO variation that can cause major, potentially life-threatening, transfusion reactions. STUDY DESIGN AND METHODS:Using multiple large-scale next-generation sequence data sets, we demonstrate the application of read-depth app...

journal_title：Transfusion

authors： Fox K,Johnsen JM,Coe BP,Frazar CD,Reiner AP,NHLBI Exome Sequencing Project, Minority Health-GRID Network.,Eichler EE,Nickerson DA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Prevalence estimates of the serious hazards of transfusion vary widely. We hypothesized that the current reporting infrastructure in the United States fails to capture many transfusion reactions and undertook a multicenter study using active surveillance, data review, and adjudication to test this hypothesis...

journal_title：Transfusion

authors： Hendrickson JE,Roubinian NH,Chowdhury D,Brambilla D,Murphy EL,Wu Y,Ness PM,Gehrie EA,Snyder EL,George Hauser R,Gottschall JL,Kleinman S,Kakaiya R,Strauss RG,National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemio

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Recent studies conducted in developed countries described hepatitis E virus (HEV) as an emerging infectious threat to blood safety. However, data on HEV among blood donors from southeast Asia are lacking. STUDY DESIGN AND METHODS:Between July and August 2014, we assessed the presence of HEV immunoglobulin (...

journal_title：Transfusion

authors： Nouhin J,Prak S,Madec Y,Barennes H,Weissel R,Hok K,Pavio N,Rouet F

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:By consensus definition, the red blood cells (RBCs) of patients that react weak to 2+ in the serologic D test are classified as having the serologic weak D phenotype (weak D). The risk of D alloimmunization in patients with weak D is not well studied. This study retrospectively determined the incidence of D ...

journal_title：Transfusion

authors： Yazer MH,Brunker PA,Bakdash S,Tobian AA,Triulzi DJ,Earnest V,Harris S,Delaney M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Advances in our understanding of the risks associated with allogeneic blood transfusions (ABTs) and the growing number of patients who wish to avoid ABTs have led to the emergence of new treatment paradigms for "bloodless" medicine and surgery. STUDY DESIGN AND METHODS:Here, we review prior studies and summ...

journal_title：Transfusion

authors： Resar LM,Wick EC,Almasri TN,Dackiw EA,Ness PM,Frank SM

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The ABO blood group is a major determinant in living donor kidney transplantation since AB antigens are expressed on renal tissue. Little attention has been directed to the ABH-secretor status of the donor kidney. As renal tissue is capable of secreting soluble ABH antigens in secretors, we examined the infl...

journal_title：Transfusion

authors： Drexler B,Holbro A,Sigle J,Gassner C,Frey BM,Schaub S,Amico P,Plattner A,Infanti L,Menter T,Mihatsch MJ,Stern M,Buser A,Dickenmann M

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Prosthetic hip-associated cobalt toxicity (PHACT) is an uncommon, but potentially devastating, complication for patients with metal-on-metal hip implants (MoMs). Clinical management of PHACT is poorly defined, with primary intervention being MoM explant followed by chelation therapy. Therapeutic plasma excha...

journal_title：Transfusion

authors： Grant ML,Karp JK,Palladino M,Le N,Hall N,Herman JH

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Techniques for banking cord blood units (CBUs) as source for hematopoietic stem cell transplantation have been developed over the past 20 years, aimed to improve laboratory efficiency without altering the biologic properties of the graft. A large-scale, registry-based assessment of the impact of the banking ...

journal_title：Transfusion

authors： Saccardi R,Tucunduva L,Ruggeri A,Ionescu I,Koegler G,Querol S,Grazzini G,Lecchi L,Nanni Costa A,Navarrete C,Pouthiers F,Larghero J,Regan D,Freeman T,Bittencourt H,Kenzey C,Labopin M,Baudoux E,Rocha V,Gluckman E

更新日期：2016-08-01 00:00:00